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공공누리This item is licensed Korea Open Government License

Title
Global Analysis of Intercellular Homeodomain Protein Transfer
Author(s)
이은정김진우정찬석
Publisher
Cell Press
Publication Year
2019-07-16
Abstract
The homeodomain is found in hundreds of transcription factors that play roles in fate determination via cell-autonomous regulation of gene expression. However, some homeodomain-containing proteins (HPs) are thought to be secreted and penetrate neighboring cells to affect the recipient cell fate. To determine whether this is a general characteristic of HPs, we carried out a large-scale validation for intercellular transfer of HPs. Our screening reveals that intercellular transfer is a general feature of HPs, but it occurs in a cell-context-sensitive manner. We also found the secretion is not solely a function of the homeodomain, but it is supported by external motifs containing hydrophobic residues. Thus, mutations of hydrophobic residues of HPs abrogate secretion and consequently interfere with HP function in recipient cells. Collectively, our study proposes that HP transfer is an intercellular communication method that couples the functions of interacting cells.
Keyword
homeodomain; cell-penetrating protein; protein secretion; intercellular protein transfer
Journal Title
Cell Reports;
Citation Volume
28
ISSN
2211-1247
DOI
10.1016/j.celrep.2019.06.056
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/16202
Fulltext
 https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=NART97534243
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