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공공누리This item is licensed Korea Open Government License

dc.contributor.author
이은정
dc.contributor.author
김진우
dc.contributor.author
정찬석
dc.date.accessioned
2022-01-11T08:26:08Z
dc.date.available
2022-01-11T08:26:08Z
dc.date.issued
2019-07-16
dc.identifier.issn
2211-1247
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/16202
dc.description.abstract
The homeodomain is found in hundreds of transcription factors that play roles in fate determination via cell-autonomous regulation of gene expression. However, some homeodomain-containing proteins (HPs) are thought to be secreted and penetrate neighboring cells to affect the recipient cell fate. To determine whether this is a general characteristic of HPs, we carried out a large-scale validation for intercellular transfer of HPs. Our screening reveals that intercellular transfer is a general feature of HPs, but it occurs in a cell-context-sensitive manner. We also found the secretion is not solely a function of the homeodomain, but it is supported by external motifs containing hydrophobic residues. Thus, mutations of hydrophobic residues of HPs abrogate secretion and consequently interfere with HP function in recipient cells. Collectively, our study proposes that HP transfer is an intercellular communication method that couples the functions of interacting cells.
dc.language.iso
eng
dc.publisher
Cell Press
dc.relation.ispartofseries
Cell Reports;
dc.title
Global Analysis of Intercellular Homeodomain Protein Transfer
dc.identifier.doi
10.1016/j.celrep.2019.06.056
dc.citation.number
3
dc.citation.volume
28
dc.contributor.approver
KOAR, ADMIN
dc.date.dateaccepted
2022-01-11T08:26:08Z
dc.date.datesubmitted
2022-01-11T08:26:08Z
dc.identifier.bibliographicCitation
vol. 28, no. 3
dc.identifier.url
https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=NART97534243
dc.subject.keyword
homeodomain
dc.subject.keyword
cell-penetrating protein
dc.subject.keyword
protein secretion
dc.subject.keyword
intercellular protein transfer
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7. KISTI 연구성과 > 학술지 발표논문
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