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공공누리This item is licensed Korea Open Government License

Title
Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling
Author(s)
구현정손은화강세찬손은수이성률장광진표석능
Publication Year
2017-08-31
Abstract
The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part(EDH-1e) and bark(EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE(-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the increased levels of tumor necrosis factor alpha(TNF-α), interleukin(IL)-6, transforming growth factor beta 1(TGF-β1), vascular cell adhesion protein 1(VCAM-1), and monocyte chemoattractant protein-1(MCP-1), and reduced infiltration of monocytes into liver tissue. The protein levels of Toll-like receptor 4(TLR4) were also downregulated by EDH-1e and EDH-2b treatment as were the levels of activator protein 1(AP-1), c-fos, and c-jun in the livers from Western-type diet-fed ApoE(-/-) mice and in lipopolysaccharide-stimulated HepG2 cells. Taken together, EDH-1e and EDH-2b attenuated hepatic inflammation and fibrosis via suppression of the TLR4-AP1-mediated signaling pathway.
Keyword
ApoE; Discorea batatas; inflammation; Toll-like receptor; Activator protein
Journal Title
Biomedicine & Pharmacotherapy
Citation Volume
92
ISSN
0753-3322
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14639
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