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공공누리This item is licensed Korea Open Government License

dc.contributor.author
구현정
dc.contributor.author
손은화
dc.contributor.author
강세찬
dc.contributor.author
손은수
dc.contributor.author
이성률
dc.contributor.author
장광진
dc.contributor.author
표석능
dc.date.accessioned
2019-08-28T07:42:05Z
dc.date.available
2019-08-28T07:42:05Z
dc.date.issued
2017-08-31
dc.identifier.issn
0753-3322
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/14639
dc.description.abstract
The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part(EDH-1e) and bark(EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE(-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the increased levels of tumor necrosis factor alpha(TNF-α), interleukin(IL)-6, transforming growth factor beta 1(TGF-β1), vascular cell adhesion protein 1(VCAM-1), and monocyte chemoattractant protein-1(MCP-1), and reduced infiltration of monocytes into liver tissue. The protein levels of Toll-like receptor 4(TLR4) were also downregulated by EDH-1e and EDH-2b treatment as were the levels of activator protein 1(AP-1), c-fos, and c-jun in the livers from Western-type diet-fed ApoE(-/-) mice and in lipopolysaccharide-stimulated HepG2 cells. Taken together, EDH-1e and EDH-2b attenuated hepatic inflammation and fibrosis via suppression of the TLR4-AP1-mediated signaling pathway.
dc.language
eng
dc.relation.ispartofseries
Biomedicine & Pharmacotherapy
dc.title
Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling
dc.citation.endPage
167
dc.citation.startPage
157
dc.citation.volume
92
dc.subject.keyword
ApoE
dc.subject.keyword
Discorea batatas
dc.subject.keyword
inflammation
dc.subject.keyword
Toll-like receptor
dc.subject.keyword
Activator protein
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7. KISTI 연구성과 > 학술지 발표논문
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