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공공누리This item is licensed Korea Open Government License

Title
Genomic Classification of Cutaneous Melanoma
Author(s)
The Cancer Genome Atlas Network강효진이준학
Publication Year
2015-06-18
Abstract
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multi-dimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.
Keyword
Cutaneous Melanoma; TCGA; LCK
Journal Title
Cell
Citation Volume
161
ISSN
1681-1696
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7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14464
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART72231505
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