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공공누리This item is licensed Korea Open Government License

dc.contributor.author
The Cancer Genome Atlas Network
dc.contributor.author
강효진
dc.contributor.author
이준학
dc.date.accessioned
2019-08-28T07:41:48Z
dc.date.available
2019-08-28T07:41:48Z
dc.date.issued
2015-06-18
dc.identifier.issn
1681-1696
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/14464
dc.identifier.uri
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART72231505
dc.description.abstract
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multi-dimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.
dc.language
eng
dc.relation.ispartofseries
Cell
dc.title
Genomic Classification of Cutaneous Melanoma
dc.citation.endPage
1696
dc.citation.startPage
1681
dc.citation.volume
161
dc.subject.keyword
Cutaneous Melanoma
dc.subject.keyword
TCGA
dc.subject.keyword
LCK
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7. KISTI 연구성과 > 학술지 발표논문
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