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공공누리This item is licensed Korea Open Government License

Title
Computational model for analyzing the evolutionary patterns of the neuraminidase gene of influenza A/H1N1
Author(s)
안인성
Publication Year
2012-02-29
Abstract
Inthisstudy,weperformedcomputersimulationstoevaluatethechangesofselectionpotentialsof
codonsininfluenzaA/H1N1from1999to2009.Weartificiallygeneratedthesequencesbyusingthe
transitionmatricesofpositivelyselectedcodonsovertime,andtheirsimilaritiesagainstthedatabase
ofinfluenzavirusAgenusweredeterminedbyBLASTsearch.Thisisthefirstapproachtopredictthe
evolutionarydirectionofinfluenzaAvirus(H1N1)bysimulatingthecodonsubstitutionsovertime.We
observedthattheBLASTresultsshowedthehighsimilaritieswithpandemicinfluenzaA/H1N1in2009,suggestingthattheclassicalhuman-origininfluenzaA/H1N1isolatedbefore2009mightcontainsomeselectionpotentialsofswine-originviruses.ComputersimulationsusingthetimeseriescodonsubstitutionpatternsresulteddramaticchangesofBLASTresultsininfluenzaA/H1N1,providingapossibilityofdevelopingamethodforpredictingtheviralevolutioninsilico.
Keyword
computersimulation; influenzaAvirus; H1N1subtype; neuraminidase; evolution
Journal Title
Computationalbiologyandchemistry
Citation Volume
36
ISSN
1476-9271
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14083
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