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- dc.contributor.author
- 안인성
- dc.date.accessioned
- 2019-08-28T07:41:13Z
- dc.date.available
- 2019-08-28T07:41:13Z
- dc.date.issued
- 2012-02-29
- dc.identifier.issn
- 1476-9271
- dc.identifier.uri
- https://repository.kisti.re.kr/handle/10580/14083
- dc.description.abstract
-
Inthisstudy,weperformedcomputersimulationstoevaluatethechangesofselectionpotentialsof
codonsininfluenzaA/H1N1from1999to2009.Weartificiallygeneratedthesequencesbyusingthe
transitionmatricesofpositivelyselectedcodonsovertime,andtheirsimilaritiesagainstthedatabase
ofinfluenzavirusAgenusweredeterminedbyBLASTsearch.Thisisthefirstapproachtopredictthe
evolutionarydirectionofinfluenzaAvirus(H1N1)bysimulatingthecodonsubstitutionsovertime.We
observedthattheBLASTresultsshowedthehighsimilaritieswithpandemicinfluenzaA/H1N1in2009,suggestingthattheclassicalhuman-origininfluenzaA/H1N1isolatedbefore2009mightcontainsomeselectionpotentialsofswine-originviruses.ComputersimulationsusingthetimeseriescodonsubstitutionpatternsresulteddramaticchangesofBLASTresultsininfluenzaA/H1N1,providingapossibilityofdevelopingamethodforpredictingtheviralevolutioninsilico.
- dc.language
- eng
- dc.relation.ispartofseries
- Computationalbiologyandchemistry
- dc.title
- Computational model for analyzing the evolutionary patterns of the neuraminidase gene of influenza A/H1N1
- dc.citation.endPage
- 30
- dc.citation.startPage
- 23
- dc.citation.volume
- 36
- dc.subject.keyword
- computersimulation
- dc.subject.keyword
- influenzaAvirus
- dc.subject.keyword
- H1N1subtype
- dc.subject.keyword
- neuraminidase
- dc.subject.keyword
- evolution
- Appears in Collections:
- 7. KISTI 연구성과 > 학술지 발표논문
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