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공공누리This item is licensed Korea Open Government License

Title
BioVLAB-MMIA: A Cloud Environment for microRNA and mRNA Integrated Analysis (MMIA) on Amazon EC2
Author(s)
이형로최동훈
Publication Year
2012-09-28
Abstract
MicroRNAs,byregulatingtheexpressionofhundredsoftargetgenes,playcriticalrolesindevelopmentalbiologyandtheetiologyofnumerousdiseases,includingcancer.AsavastamountofmicroRNAexpressionprofiledataarenowpubliclyavailable,theintegrationofmicroRNAexpressiondatasetswithgeneexpressionprofilesisakeyresearchprobleminlifescienceresearch.However,theabilitytoconductgenome-widemicroRNA-mRNA(gene)integrationcurrentlyrequiressophisticated,high-endinformaticstools,significantexpertiseinbioinformaticsandcomputersciencetocarryoutthecomplexintegrationanalysis.Inaddition,increasedcomputinginfrastructurecapabilitiesareessentialinordertoaccommodatelargedatasets.Inthisstudy,wehaveextendedtheBioVLABcloudworkbenchtodevelopanenvironmentfortheintegratedanalysisofmicroRNAandmRNAexpressiondata,namedBioVLAB-MMIA.TheworkbenchfacilitatescomputationsontheAmazonEC2andS3resourcesorchestratedbytheXBayaWorkflowSuite.TheadvantagesofBioVLAB-MMIAovertheweb-basedMMIAsysteminclude:1)readilyexpandedasnewcomputationaltoolsbecomeavailable2)easilymodifiablebyre-configuringgraphiciconsintheworkflow3)on-demandcloudcomputingresourcescanbeusedonanasneededbasis4)distributedorchestrationsupportscomplexandlongrunningworkflowsasynchronously.WebelievethatBioVLAB-MMIAwillbeaneasy-to-usecomputingenvironmentforresearcherswhoplantoperformgenome-widemicroRNA-mRNA(gene)integratedanalysistasks.
Keyword
scientificworkflow; cloudcomputing; microRNAs; mRNAs
Journal Title
IEEETransactionsonNanoBioScience
Citation Volume
11
ISSN
1536-1241
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14069
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART64808416
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