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공공누리This item is licensed Korea Open Government License

dc.contributor.author
이형로
dc.contributor.author
최동훈
dc.date.accessioned
2019-08-28T07:41:11Z
dc.date.available
2019-08-28T07:41:11Z
dc.date.issued
2012-09-28
dc.identifier.issn
1536-1241
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/14069
dc.identifier.uri
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART64808416
dc.description.abstract
MicroRNAs,byregulatingtheexpressionofhundredsoftargetgenes,playcriticalrolesindevelopmentalbiologyandtheetiologyofnumerousdiseases,includingcancer.AsavastamountofmicroRNAexpressionprofiledataarenowpubliclyavailable,theintegrationofmicroRNAexpressiondatasetswithgeneexpressionprofilesisakeyresearchprobleminlifescienceresearch.However,theabilitytoconductgenome-widemicroRNA-mRNA(gene)integrationcurrentlyrequiressophisticated,high-endinformaticstools,significantexpertiseinbioinformaticsandcomputersciencetocarryoutthecomplexintegrationanalysis.Inaddition,increasedcomputinginfrastructurecapabilitiesareessentialinordertoaccommodatelargedatasets.Inthisstudy,wehaveextendedtheBioVLABcloudworkbenchtodevelopanenvironmentfortheintegratedanalysisofmicroRNAandmRNAexpressiondata,namedBioVLAB-MMIA.TheworkbenchfacilitatescomputationsontheAmazonEC2andS3resourcesorchestratedbytheXBayaWorkflowSuite.TheadvantagesofBioVLAB-MMIAovertheweb-basedMMIAsysteminclude:1)readilyexpandedasnewcomputationaltoolsbecomeavailable2)easilymodifiablebyre-configuringgraphiciconsintheworkflow3)on-demandcloudcomputingresourcescanbeusedonanasneededbasis4)distributedorchestrationsupportscomplexandlongrunningworkflowsasynchronously.WebelievethatBioVLAB-MMIAwillbeaneasy-to-usecomputingenvironmentforresearcherswhoplantoperformgenome-widemicroRNA-mRNA(gene)integratedanalysistasks.
dc.language
eng
dc.relation.ispartofseries
IEEETransactionsonNanoBioScience
dc.title
BioVLAB-MMIA: A Cloud Environment for microRNA and mRNA Integrated Analysis (MMIA) on Amazon EC2
dc.citation.endPage
272
dc.citation.number
3
dc.citation.startPage
266
dc.citation.volume
11
dc.subject.keyword
scientificworkflow
dc.subject.keyword
cloudcomputing
dc.subject.keyword
microRNAs
dc.subject.keyword
mRNAs
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7. KISTI 연구성과 > 학술지 발표논문
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