Recently US/EU governments are utilizing nanotechnology as a key catalyst to support national innovation policies with economic recovery goals. US/EU nano policies have been serving as a global model to various countries, including Korea. So the authors initially seek to understand US/EU national innovation policy interconnections, and then find the role of nanotechnology development within. To strengthen national policy coherence, nanotechnology development strategies are under evolution as an innovation catalyst for promoting commercialization. To strategically support nano commercialization, EHS (Environmental, Health, Safety) and informatics are invested as priority fields to strengthen social acceptance and sustainability of nano enabled products. The current study explores US/EU national innovation policies including nano commercialization, EHS, and Informatics. Then obtained results are utilized to analyze weaknesses of Korean innovation systems of connecting creative economy and nanotechnology development policies. Then ongoing improvements are summarized focusing on EHS and informatics, which are currently prominent issues in international nanotechnology development.