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공공누리This item is licensed Korea Open Government License

Title
Confinement induces helical organization of chromosome-like polymers
Author(s)
Jung, YoungkyunHa, Bae-Yeun
Publisher
Nature Publishing Group
Publication Year
2019-01-29
Abstract
Helical organization is commonly observed for a variety of biopolymers. Here we study the helical organization of two types of biopolymers, i.e., DNA-like semiflexible and bottle-brush polymers, in a cell-like confined space. A bottle-brush polymer consists of a backbone and side chains emanating from the backbone, resembling a supercoiled bacterial chromosome. Using computer simulations, we calculate ‘writhe’ distributions of confined biopolymers for a wide range of parameters. Our effort clarifies the conditions under which biopolymers are helically organized. While helical organization is not easily realized for DNA-like biomolecules, cylindrical confinement can induce spiral patterns in a bottle brush, similarly to what was observed with bacterial chromosomes. They also suggest that ring-shape bottle brushes have a stronger tendency for helical organization. We discuss how our results can be used to interpret chromosome experiments. For instance, they suggest that experimental resolution has unexpected consequences on writhe measurements (e.g., narrowing of the writhe distribution and kinetic separation of opposite helical states).
Keyword
공간구조; 염색체; 고분자; 분자동역학; conformation; chromosome; polymer; molecular dynamics
Journal Title
Scientific reports;
Citation Volume
9
ISSN
2045-2322
DOI
10.1038/s41598-018-37261-8
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/16563
Fulltext
 https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=NART95598853
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