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공공누리This item is licensed Korea Open Government License

Title
Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia
Author(s)
백효정Butte, Atul J.Manber, Udi조성범Chen, BinSirota, MarinaHadley, DexterRappoport, NadavKan, Matthew J.
Publisher
Nature Publishing Group
Publication Year
2019-10-15
Abstract
AbstractThe identification of novel disease associations using big-data for patient care has had limited success. In this study, we created a longitudinal disease network of traced readmissions (disease trajectories), merging data from over 10.4 million inpatients through the Healthcare Cost and Utilization Project, which allowed the representation of disease progression mapping over 300 diseases. From these disease trajectories, we discovered an interesting association between schizophrenia and rhabdomyolysis, a rare muscle disease (incidence < 1E-04) (relative risk, 2.21 [1.80-2.71, confidence interval = 0.95], P-value 9.54E-15). We validated this association by using independent electronic medical records from over 830,000 patients at the University of California, San Francisco (UCSF) medical center. A case review of 29 rhabdomyolysis incidents in schizophrenia patients at UCSF demonstrated that 62% are idiopathic, without the use of any drug known to lead to this adverse event, suggesting a warning to physicians to watch for this unexpected risk of schizophrenia. Large-scale analysis of disease trajectories can help physicians understand potential sequential events in their patients.
Keyword
네트워크; 의료바이오; 조현병; Network; Biomedical; Schizophrenia
Journal Title
Scientific data;
Citation Volume
6
ISSN
2052-4463
DOI
10.1038/s41597-019-0220-5
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/16253
Fulltext
 https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=NART109838814
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