Governments are asking policymakers to quantify the economic and social impact of those advanced technologies they support, including nanotechnology. National policymakers and researchers who participated in OECD activities cooperated to develop a model for the economic impact assessment of nanotechnology with a relevant case study. The present research contributing to some recommendations from the OECD WPN (Working Party on Nanotechnology) finds a successful example of market creation by nanotechnology, and assesses the resulting economic impact of the DEFRA (Department of Environment, Food & Rural Affairs of UK) model. This study investigates the economic impact of Quantum-dot (Qdot) nanotechnology on flat panel TV manufacturers, which is an ideal case to apply the DEFRA model for the analysis of product innovation based on nanotechnology. Findings show that Qdot nanotechnology is expected to create an economic value of $3.32 billion for Korean TV manufacturers over the next decade.