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공공누리This item is licensed Korea Open Government License

Title
How are molecular crowding and the spatial organization of a biopolymer interrelated
Author(s)
전찬일정영균Changbong Hyeon배은하
Publication Year
2016-12-16
Abstract
In a crowded cellular interior, dissolved biomolecules or crowders exert excluded volume effects on other biomolecules, which in turn control various processes including protein aggregation and chromosome organization. As a result of these effects, a long chain molecule can be phase-separated into a condensed state, redistributing the surrounding crowders. Using computer simulations and a theoretical approach, we study the interrelationship between molecular crowding and chain organization. In a parameter space of biological relevance, the distributions of monomers and crowders follow a simple relationship: the sum of their volume fractions rescaled by their size remains constant. Beyond a physical picture of molecular crowding it offers, this finding explains a few key features of what has been known about chromosome organization in an E. coli cell.
Keyword
Crowding; biopolymer; molecular dynamics
Journal Title
Soft Matter
ISSN
1744-683X
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14544
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART77498706
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