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공공누리This item is licensed Korea Open Government License

Title
Effects of molecular crowding and confinement on the spatial organization of a biopolymer
Author(s)
전찬일정영균배은하
Publication Year
2016-12-09
Abstract
A chain molecule can be entropically collapsed in a crowded medium in a free or confined space. Here, we present a unified view of how molecular crowding collapses a flexible polymer in three distinct spaces: free, cylindrical, and (two-dimensional) slit-like. Despite their seeming disparities, a few general features characterize all these cases, even though the fc-dependence of chain compaction differs between the two cases. Chain size depends on the ratio a phi/ac, and ‘‘full’’ compaction occurs universally at a phi/ac; it is controlled by fc alone and crowding has a modest effect on chain size in a cellular environment. Also for a typical parameter range of biological relevance, molecular crowding can be viewed as effectively reducing the solvent quality, independent of confinement.
Keyword
Crowding; biopolymer; molecular dynamics
Journal Title
Soft Matter
ISSN
1744-683X
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14543
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART77555104
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