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공공누리This item is licensed Korea Open Government License

Title
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
Author(s)
Fengju ChenChad J. Creighton강효진이준학
Publication Year
2016-03-15
Abstract
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset.
Keyword
Renal Cell Carcinoma; Genomics; Taxonomy
Journal Title
Cell Reports
Citation Volume
14
ISSN
2211-1247
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7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14503
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART75089099
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