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공공누리This item is licensed Korea Open Government License

Title
Network Comparison of Inflammation in Colorectal Cancer and Alzheimer’s Disease
Author(s)
박성진남승윤Curt Balch김용희유석종이진혁조용성
Publication Year
2015-07-26
Abstract
Recently, a large clinical study revealed an inverse correlation of individual risk of cancer versus Alzheimer’s disease (AD). However, no explanation exists for this anticorrelation at the molecular level; however, inflammation is crucial to the pathogenesis of both diseases, necessitating a need to understand differing signaling usage during inflammatory responses distinct to both diseases. Using a subpathway analysis approach, we identified numerous well-known and previously unknown pathways enriched in datasets from both diseases. Here, we present the quantitative importance of the inflammatory response in the two disease pathologies and summarize signal transduction pathways common to both diseases that are affected by inflammation.
Keyword
network; signal transduction pathway; colorectal cancer; Alzheimer's disease; inflammation
Journal Title
BioMed Research International
Citation Volume
2015
ISSN
2314-6133
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14468
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART76636794
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