download0 view191
twitter facebook

공공누리This item is licensed Korea Open Government License

Title
Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells
Author(s)
임정대손은화강세찬구현정김나리김태성김형규남궁승백종필손은수송인성이성렬장선아한진
Publication Year
2015-02-16
Abstract
Fucoidan is an L-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1, a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-beta1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooxygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions
Keyword
fucoidan; Fucus vesiculosus; alcohol induced liver damage; inflammatory mediator; hepatoprotective effect
Journal Title
Marine drugs
Citation Volume
13
ISSN
1660-3397
Files in This Item:
There are no files associated with this item.
Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14390
Export
RIS (EndNote)
XLS (Excel)
XML

Browse