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공공누리This item is licensed Korea Open Government License

Title
Chromosome-like organization of an asymmetrical ring polymer confined in a cylindrical space
Author(s)
전찬일정영균김주인전하웅하배연
Publication Year
2015-11-07
Abstract
To what extent does a confined polymer show chromosome-like organization? Using molecular dynamics simulations, we study a model Escherichia coli (E. coli) chromosome: an asymmetrical ring polymer, formed by small monomers on one side and big monomers on the other confined in a concentric-shell or simple cylinder with closed ends. The ring polymer is organized in the way observed for the E. coli chromosome: if the big monomers are assumed to be localized in the inner cylinder, the two “subchains” forming the ring are spontaneously partitioned in a parallel orientation with the “body” (big-monomer) chain linearly organized with a desired precision and the crossing (small-monomer) chain residing preferentially in the peripheral region. Furthermore, we show that the introduction of a “fluctuating boundary” between the two subchains leads to a double-peak distribution of ter-proximate loci, as seen in experiments, which would otherwise remain single-peaked. In a simple cylinder, however, a chromosome-like organization of the ring polymer typically requires an external mechanism such as cell-wall attachment. Finally, our results clarify to what degree the spatial organization of the chromosomes can be accomplished solely by ring asymmetry and anisotropic confinement.
Keyword
Bacteria; polymer'molecular dynamics
Journal Title
Soft Matter
Citation Volume
11
ISSN
1744-683X
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7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14384
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART73327885
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