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Title
A polymer in a crowded and confined space: effects of crowder size and poly-dispersity
Author(s)
김주인정영균전찬일전하웅하배연
Publication Year
2015-03-14
Abstract
DNA compaction in a bacterial cell is in part carried out by entropic (depletion) forces induced by “free” proteins or crowding particles in the cytoplasm. Indeed, recent in vitro experiments highlight these effects by showing that they alone can condense the E. coli chromosome to its in vivo size. Using molecular dynamics simulations and a theoretical approach, we study how a flexible chain molecule can be compacted by crowding particles with variable sizes in a (cell-like) cylindrical space. Our results show that with smaller crowding agents the compaction occurs at a lower volume fraction but at a larger concentration such that doubling their size is equivalent to increasing their concentration fourfold. Similarly, the effect of polydispersity can be correctly mimicked by adjusting the size of crowders in a homogeneous system. Under different conditions, however, crowding particles can induce chain adsorption onto the cylinder wall, stretching the chain, which would otherwise remain condensed
Keyword
chromosome; crowding; polymer; molecular dynamics
Journal Title
Soft Matter
Citation Volume
11
ISSN
1744-683X
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7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14382
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART71522481
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