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공공누리This item is licensed Korea Open Government License

Title
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
Author(s)
CalebF.Davis강효진이준학
Publication Year
2014-09-08
Abstract
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
Keyword
kidney cancer; mutation; chromophobe renal cell carcinoma; whole genome sequence; TERT
Journal Title
Cancer cell
ISSN
1535-6108
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14357
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART70271342
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