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The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-kB and JNK/p38 MAPK activation
Publication Year
Fruits of the Litsea family of trees and shrubs contain biologically active compounds, some of which have been used
as natural nutrients and flavoring agents in food. In this study,we identified novel anti-nociceptive effects of the 30%
ethanol extract, the CH2Cl2 fraction and the associated active components (Hamabiwalactone A and B) from Litsea
japonica fruit by using in vivo peripheral and central nervous pain models. In addition, we compared the antiinflammatory
effects of several fractions from L. japonica fruit extracts using lipopolysaccharide (LPS)-stimulated
Raw264.7 cells. The CH2Cl2 fraction of L. japonica fruit (LJM) had an optimal combination of anti-inflammatory effects
and low cytotoxicity. Dose response studies were performed to determine the inhibitory effects of LJM on
the pro-inflammatory enzymes, COX-2/PGE2 and NO/iNOS, and pro-inflammatory cytokines, IL-1β, IL-6, and TNF-
α. Molecular profiling revealed that LJM exerts anti-inflammatory effects through inhibition of NF-κB and JNK/
p38 MAPK signaling in LPS-induced macrophages. This study suggests that CH2Cl2 fraction of L. japonica fruit and
its bioactive components are potential candidates as anti-inflammatory and analgesic agents (painkillers) for the
treatment of inflammatory diseases.
Journal Title
International Immunopharmacology
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7. KISTI 연구성과 > 학술지 발표논문
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