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공공누리This item is licensed Korea Open Government License

Title
A community computational challenge to predict the activity of pairs of compounds
Author(s)
MukeshBansal이준학
Publication Year
2014-11-17
Abstract
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergistic to the most antagonistic, based on gene-expression profiles of human B cells treated with individual compounds at multiple time points and concentrations. Using scoring metrics based on experimental dose-response curves, we assessed 32 methods (31 community-generated approaches and SynGen), four of which performed significantly better than random guessing. We highlight similarities between the methods. Although the accuracy of predictions was not optimal, we
find that computational prediction of compound-pair activity is possible, and that community challenges can be useful to advance the field of in silico compound-synergy prediction.
Journal Title
Nature Biotechnology
ISSN
1087-0156
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14296
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART71086668
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