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공공누리This item is licensed Korea Open Government License

Title
Novel inhibitory function of miR-125b in melanogenesis
Author(s)
김규한강효진유석종
Publication Year
2013-10-07
Abstract
MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets to treat skin diseases. In this study, miR-125b was identified as a potent regulator of steady-state melanogenesis. We found that the expression of miR-125b was inversely related to pigment levels. A miR-125b mimic decreased the expression of pigmentation-related gene and melanin content, implying that miR-125b functions to decrease pigmentation. Moreover, we observed that the reduction in miR-125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B-1 promoter, and miR-125b expression was regulated by intracellular cAMP levels
Keyword
melanogenesis; inhibitory function
Journal Title
Pigment cell & melanoma research
ISSN
1755-1471
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/14194
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