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Title
Ring polymers as model bacterial chromosomes: confinement, chain topology, single chain statistics, and how they interact
Author(s)
정영균
Publication Year
2011-11-03
Abstract
Chromosomes in living cells are strongly con?ned but show a high level of spatial organization.
Similarly, con?ned polymers display intriguing organizational and segregational properties. Here, we
discuss how ring topology in?uences self-avoiding polymers con?ned in a cylindrical space, i.e.
individual polymers as well as the way they interact. Our molecular dynamics simulations suggest that
a ring polymer can be viewed as a parallel connection of two linear subchains, each trapped in
a narrower imaginary tube. As a consequence, ring topology stiffens individual chains about ?vefold
and enhances their segregation appreciably, as if it induces extra linear ordering. Using
a renormalized Flory approach, we show how ring topology in?uences individual chains in the long
chain limit. Our polymer model quantitatively explains the long-standing observations of chromosome
organization and segregation in E. coli.
Keyword
Molecular dynamics; Bacteria; DNA
Journal Title
Soft matter
Citation Volume
8
ISSN
1744-683x
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/13976
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