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공공누리This item is licensed Korea Open Government License

Title
Glucosylation of the flavonoid, astragalin by Leuconostoc mesenteroides B-512FMCM dextransucrase acceptor reactions and characterization of the products
Author(s)
안설아
Publication Year
2011-09-24
Abstract
Astragalin (kaempferol-3-O-Beta-D-glucopyranoside, Ast) glucosides were synthesized by the acceptor reaction of a dextransucrase produced by Leuconostoc mesenteroides B-512FMCM with astragalin and sucrose. Each glucoside was purified and their structures were assigned as kaempferol-3-O-Beta-D-glucopyranosyl-(from 1 to 3)-O-Alpha-d-glucopyranoside (or kaempferol-3-O-Beta-D-nigeroside, Ast-G1 prime) and kaempferol-3-O-Beta-D-glucopyranosyl-(from 1 to 6)-O-Alpha-D-glucopyranoside (or kaempferol-3-O-Beta-D-isomaltoside, Ast-G1) for one glucose transferred, and kaempferol-3-O-Beta-D-isomaltooligosacharide (Ast-IMO or Ast-Gn, n = 2-8). The astragalin glucosides exhibited 8.3-60.6% higher inhibitory effects on matrix metalloproteinase-1 expression, 18.8-20.3% increased antioxidant effects, and 3.8-18.8% increased inhibition activity of melanin synthesis compared to control (without the addition of compound), depending on the number of glucosyl residues linked to astragalin. These novel compounds could be used to further expand the industrial applications of astragalin glucosides, in particular in the cosmetics industry.
Keyword
Dextransucrase; Astragalin; Transglucosylation; Acceptor reaction; Kaempferol; Melanogenesis inhibition
Journal Title
Enzyme and microbial technology
Citation Volume
50
ISSN
0141-0229
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/13952
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