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공공누리This item is licensed Korea Open Government License

Title
Effects of Halothane on Dimyristoylphosphatidylcholine Lipid Bilayer Structure:
Author(s)
오광진
Publication Year
2009-11-09
Abstract
We performed molecular dynamics simulations on dimyristoylphosphatidylcholine lipid bilayer with 50 mol%
halothane. The structural properties, electron density profile, segmental order parameter of acyl chains, headgroup
orientation distribution, water dipole orientation distribution, have been examined. Overall the effects of the
halothane molecules on structural properties of DMPC lipid bilayer were found to be small. The electron density
profiles, the segmental order parameter, the headgroup orientation, the water dipole orientation were not affected
significantly by the halothane molecules. Pressure tensor calculations shows that the lateral pressure increases at the
hydrocarbon tail region and the headgroup region, and decreases at the water-headgroup interfacial region.
Keyword
Molecular dynamics simulation; lipid bilayer; anesthetics
Journal Title
Bulletin of the Korean Chemical Society
Citation Volume
30
ISSN
0253-2964
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/13748
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