Amphiphilic multiblock Tetronic-PCL copolymer was synthesized by a ring-opening polymerization of e-caprolactone with Tetronic by using stannous octoate as a catalyst, and Tetronic-PCL-heparin conjugate was prepared by coupling heparin with Tetronic-PCL copolymer by using EDC/NHS as coupling agents.~~~
Keyword
Tetronic; Heparin; Biodegradable polymer; Micelle; Drug delivery system