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공공누리This item is licensed Korea Open Government License

Title
Epidemiological comparisons of codon usage patterns among HIV-1 isolates from Asia, Europe, Africa and the Americas
Author(s)
안인성손현석
Publication Year
2006-12-28
Abstract
To investigate the genomic properties of HIV-1, we collected 3,081 sequences from the HIV Sequence Database. The sequences were categorized according to sampling region, country, year, subtype, gene name, and sequence and were saved in a database constructed for this study. The RSCU values of matrix, capsid, and gp120 and gp41 genes were calculated using correspondence analysis. The synonymous codon usage patterns based on the geographical regions of African countries showed broad distributions; when all the other regions, including Asia, Europe, and the Americas, were taken into account, the Asian countries tended to be divided into two groups. The sequences were clustered into nine non-CRF subtypes. Among these, subtype C showed the most distinct codon usage pattern. To determine why the codon usage patterns in Asian countries were divided into two groups for four target genes, the sequences of the isolates from the Asian countries were analyzed.
Keyword
Bioinformatics; correspondence analysis; HIV-1 subtype; codon usage pattern
Journal Title
Experimental & molecular medicine
Citation Volume
38
ISSN
1226-3613
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Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/13620
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART31062564
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