download0 view126
twitter facebook

공공누리This item is licensed Korea Open Government License

Title
Synthesis and characterization of thermosensitive chitosan copolymer as a novel biomaterial
Author(s)
이준우박기동박형달유규하정명철
Publication Year
2004-08-02
Abstract
Novel water-soluble thermosensitive chitosan copolymers were prepared by graft polymerization of N-isopropylacrylamide (NIPAAm) onto chitosan using cerium ammonium nitrate (CAN) as an initiator. Sol-gel transition behavior was investigated by the cloud point measurement of the chitosan-g-NIPAAm aqueous solution. The gelling temperature was examined by vial inversion method. The percentage of grafting (%) and efficiency of grafting (%) were investigated according to concentrations of monomer and initiator.
Water-soluble chitosan-g-NIPAAm copolymers were prepared successfully and they formed thermally reversible hydrogel, which exhibits a lower critical solution temperature (LCST) around 32℃ in aqueous solutions. Preliminary in-vitro cell study showed nontoxic and biocompatible properties. These results suggest that chitosan-g-NIPAAm copolymer would be very useful in biomedical and pharmaceutical applications as an injectable material for cell and drug delivery.
Keyword
Chitosan; Hydrogel; Thermally responsive material; N-isopropyl acrylamide (NIPAAm); Cell viability
Journal Title
Journal of biomaterials science. Polymer edition
Citation Volume
15
ISSN
0920-5063
Files in This Item:
There are no files associated with this item.
Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
URI
https://repository.kisti.re.kr/handle/10580/13571
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART22884873
Export
RIS (EndNote)
XLS (Excel)
XML

Browse