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공공누리This item is licensed Korea Open Government License

Title
초고성능컴퓨팅 기반 건강한 고령사회 대응 빅데이터 기술 개발
Alternative Title
Development of biomedical data network analysis technology based on high performance computing for dementia researches
Author(s)
이민호유석종안인성강효진이명화김영훈이용김주현이준학박경석그외 다수
Alternative Author(s)
Lee, Min-Ho; Yu, Seok-Jong; An, In-Seong; Gang, Hyo-Jin; Lee, Myeong-Hwa; Kim, Yeong-Hun; Lee, Yong; Kim, Ju-Hyeon; Lee, Jun-Hak; Park, Gyeong-Seok; et al
Publisher
한국과학기술정보연구원
Korea Institute of Science and Technology Information
Publication Year
2016-01
Description
funder : 미래창조과학부
funder : KA
agency : 한국과학기술정보연구원
agency : Korea Institute of Science and Technology Information
Abstract
본 연구과제의 목적은 HPC(High Performance Computing) 및 데이터 기반의 질병 연구를 위한 분석 기술의 개발임. 이를 위해, 본 연구과제는 당해 연도에 다음과 같이 수행되었음.
○ 노인성 치매 대응을 위한 치매 데이터 네트워크 분석 기술 확보
○ 치매 발병 메커니즘에 대한 가상 실험을 위한 모델링 및 시뮬레이션 기술 개발
○ 치매 연구 지원 시스템 개발 및 확산
○ 감염병 대응을 위한 변이 및 확산 예측 기술 개발

Ⅳ. Results of the study
○ Development of the core methodology to analyze bio-medical big data
- Construction of the database to store and manage of public biological dataset
- Identification of the disease related entities and their relationships from 28 million PubMed dataset by applying text mining (F1-score :81%)
- Development of the novel clustering and sub-network matching algorithms (increase of clustering and sub-network matching accuracy compared to MCL(300%) and VF2(500%), respectively)
○ Development and application of the prototype analysis platform on network and genome data for Alzheimer's disease research
- Construction of the storage for genome data (600TB) and pipeline with seven algorithms to analyze genomic variation
- Collaboration with overseas research institutes and publishing two papers in Cell by supporting genomic data analysis
- Development of the prototype analysis systems based on the big data processing platform with web interface (user’s satisfaction score: 93 out of 100 points)
○ Organization of the national communities for disease experts
- Holding three Alzheimer's disease expert’s meetings and thirteen technical seminars
- Creation of the nine expert’s technical reports for discovering diffusion model of infectious disease and holding a KISTI policy research forum
Keyword
Dementia Screening; Dementia Data Network; Data Network; Data Mining; Bio-Medical Bigdata
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Appears in Collections:
7. KISTI 연구성과 > 연구보고서 > 2016
URI
https://repository.kisti.re.kr/handle/10580/11310
http://www.ndsl.kr/ndsl/search/detail/report/reportSearchResultDetail.do?cn=TRKO201600000490
Fulltext
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