생명정보 인프라 구축

Abstract

본 연구개발은 국내 생명공학 연구개발 발전을 위해 바이오인포매틱스 인프라를 구축하고 이를 연구자들에게 제공하는 것이다. 이를 위해 연구개발 분야와 사업 분야로 나누어 생명정보 분석도구의 개발, 생명정보 사용자 지원, 생명정보 콘텐트 구축 및 유지보수 등을 추진하였다. (1) 연구개발 분야 ○ 신호전달 DB 구축 및 네비게이션 시스템 개발 ○ M ultiplex PCR Primer 설계 프로그램 개발 ○ 단백질 접힘 연구 ○ Decoy에서의 DNA-Protein 상호작용 규명 연구 ○ Bio-W orkflow 개발 ○ 생명정보 컨텐트 구축 및 유지보수 (2) 사업 분야 ○ 사용자지원 및 서비스 ○ 웹서비시스 체제 구축 ○ CODATA 국제협력

The main contents and scope of the study are the following: ○ Construction of Signal Transduction DB and Development of Navigation System - Construction of Signal Transduction Network DB using integrated DB - Development of STML(Signal Transduction Markup Language) in order to represent the relationship between proteins ○ Development of Program for Multiplex PCR Primer Design - Development of the Selection for dimer formation between primers - Development of new scoring method for optimal primer selection - Development of new indexing method for genomic sequence information - Development of the search method for primer 3' at PCR simulation ○ Protein Folding Study - Study existing results and hypothesis for basic mechanism on protein folding - Development and design of new method on protein folding ○ Study on the DNA-Protein Interaction at Decoy - Collecting the structural information on Decoy and Proteins - Simulation Study on interactions - Prediction of optimal hydrogen bond ○ Bio-Workflow Development - Development of Bio-Workflow Engine based on Java and XML - Development of Java GUI-based Bio-Workflow Builder - Development of Web-Services-based and User's Role-based Bio-Workflow for remote collaboration through e-Science ○ Construction of Bioinform atics Content and System - HW and technical support - Development and Maintenance of Center Homepage - DB update - Mirroring of DBs and Analysis Tools - Publishing Newsletters ○ User Support and Services - Surveying the user's requirement and satisfaction - Hoding domestic/international symposium on bioinformatics - Public Relations of CCBB and PR support for other centers and KISTI - Maintaining DBs (biodiversity, Virtual Korean Hum an, etc.) and Providing the DB Service ○ Construction of Web-Services System - PR & Management of CCBB-UDDI Registry specialized for Bioinform atics - Development of new Web-Services and Construction of Security and Management System ○ International collaboration of CODATA - Hosting CODATA/DSAO TG Secretariat in CCBB, KISTI - Performing a representative of Korea in CODATA/DASO and developing/maintaining the CODATA/DASO homepage - Submitting the progress report of Korean's CODATA activity