This item is licensed Korea Open Government License
Atul J Butte
The decreasing cost of genomic technologies has enabled the molecular characterization of large-scale clinical disease samples and of molecular changes upon drug treatment in various disease models. Exploring methods to relate diseases to potentially efﬁcacious drugs through various molecular features is critically important in the discovery of new therapeutics. Here we show that the potency of a drug to reverse cancer-associated gene expression changes positively correlates with that drug’s efﬁcacy in preclinical models of breast, liver and colon cancers. Using a systems-based approach, we predict four compounds showing high potency to reverse gene expression in liver cancer and validate that all four compounds are effective in ﬁve liver cancer cell lines. The in vivo efﬁcacy of pyrvinium pamoate is further conﬁrmed in a subcutaneous xenograft model. In conclusion, this systems-based approach may be complementary to the traditional target-based approach in connecting diseases to potentially efﬁcacious drugs.
Reversal of cancer gene expression correlates with drug efﬁcacy and reveals therapeutic targets