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공공누리This item is licensed Korea Open Government License

dc.contributor.author
Chanil Jeon
dc.contributor.author
정영균
dc.contributor.author
Bae-Yeun Ha
dc.date.accessioned
2019-08-28T07:42:03Z
dc.date.available
2019-08-28T07:42:03Z
dc.date.issued
2017-09-19
dc.identifier.issn
2045-2322
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/14619
dc.identifier.uri
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART79113962
dc.description.abstract
Macromolecular crowding influences various cellular processes such as macromolecular association and transcription, and is a key determinant of chromosome organization in bacteria. To what extent is the circular bacterial chromosome, often viewed as consisting of “two arms,” organized entropically by crowding? Using computer simulations, we examine how a ring polymer is organized in a crowded and cylindrically-confined space, as a coarse-grained bacterial chromosome. Our results suggest that in a wide parameter range of biological relevance crowding is essential for separating the two arms in the way observed with Escherichia coli chromosomes at fast-growth rates. Under di↵erent conditions, however, the ring polymer is centrally condensed or adsorbed onto the cylindrical wall with the two arms laterally collapsed onto each other.
dc.language
eng
dc.relation.ispartofseries
SCIENTIFIC REPORTS
dc.title
A ring-polymer model shows how macromolecular crowding controls chromosome-arm organization in Escherichia coli
dc.citation.endPage
10
dc.citation.number
11896
dc.citation.startPage
1
dc.citation.volume
7
dc.subject.keyword
bacteria
dc.subject.keyword
chromosome
dc.subject.keyword
spatial organization
dc.subject.keyword
molecular dynamics
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7. KISTI 연구성과 > 학술지 발표논문
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