The application of semantic technologies to the integration of biological data and the interoperability of
bioinformatics analysis and visualization tools has been the common theme of a series of annual BioHackathons
hosted in Japan for the past five years. Here we provide a review of the activities and outcomes from the
BioHackathons held in 2011 in Kyoto and 2012 in Toyama. In order to efficiently implement semantic technologies
in the life sciences, participants formed various sub-groups and worked on the following topics: Resource Description
Framework (RDF) models for specific domains, text mining of the literature, ontology development, essential metadata
for biological databases, platforms to enable efficient Semantic Web technology development and interoperability, and
the development of applications for Semantic Web data. In this review, we briefly introduce the themes covered by
these sub-groups. The observations made, conclusions drawn, and software development projects that emerged from
these activities are discussed.