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공공누리This item is licensed Korea Open Government License

dc.contributor.author
유석종
dc.contributor.author
ThaiQuangTung
dc.date.accessioned
2019-08-28T07:41:10Z
dc.date.available
2019-08-28T07:41:10Z
dc.date.issued
2012-10-31
dc.identifier.issn
0374-4884
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/14057
dc.identifier.uri
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART64985035
dc.description.abstract
Toachieverobustnessagainstlivingenvironments,alivingorganismiscomposedofcomplicated
regulatorymechanismsrangingfromgeneregulationstosignaltransduction.Ifsuchlifephenomena
aretobeunderstand,anintegratedanalysistoolthatshouldhavemodelingandsimulation
functionsforbiologicalreactions,aswellasnewexperimentalmethodsformeasuringbiologicalphenomena,
isfundamentallyrequired.Wehavedesignedandimplementedmodelingandsimulation
software(ezBioNet)foranalyzingbiologicalreactionnetworks.Thesoftwarecansimultaneously
performanintegratedmodelingofvariousresponsesoccurringincells,rangingfromgeneexpressions
tosignalingprocesses.Tosupportmassiveanalysisofbiologicalnetworks,wehaveconstructed
aserver-sidesimulationsystem(VCellSim)thatcanperformordinarydifferentialequations(ODE)
analysis,sensitivityanalysis,andparameterestimates.ezBioNetintegratestheBioModeldatabase
byconnectingtheeuropeanbioinformaticsinstitute(EBI)serversthroughWebservicesAPIsand
supportsthehandlingofsystemsbiologymarkuplanguage(SBML)files.Inaddition,weemployed
eclipseRCP(richclientplatform)whichisapowerfulmodularityframeworkallowingvariousfunctional
expansions.ezBioNetisintendedtobeaneasy-to-usemodelingtool,aswellasasimulation
system,tounderstandthecontrolmechanismbymonitoringthechangeofeachcomponentina
biologicalnetwork.Aresearchermayperformthekineticmodelingandexecutethesimulation.
ThesimulationresultcanbemanagedandvisualizedonezBioNet,whichisfreelyavailableat
http://ezbionet.cbnu.ac.kr.
dc.language
eng
dc.relation.ispartofseries
JournaloftheKoreanPhysicalSociety
dc.title
ezBioNet: A Modeling and Simulation System for Analyzing Biological Reaction Networks
dc.citation.number
8
dc.citation.startPage
1267
dc.citation.volume
61
dc.subject.keyword
Systemsbiology
dc.subject.keyword
Simulation
dc.subject.keyword
Biologicalnetwork
dc.subject.keyword
Signaltransductionanalysis
Appears in Collections:
7. KISTI 연구성과 > 학술지 발표논문
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