Computational Three-Residue Fragment Assembly and Folding Optimization for Protein Structure Design

Abstract

Computational modeling of the unique tertiary structure of a protein from its amino acid sequence alone is one of the important challenges in science and technology. The tertiary structure itself and the folding mechanism toward it are indispensable for understanding the function and biological role of the protein. One of the computational methods often used for this modeling is the fragment assembly method because it shows good structural modeling performance in many cases. There are limitation