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공공누리This item is licensed Korea Open Government License

dc.contributor.author
이상민
dc.contributor.author
손일엽
dc.contributor.author
박형욱
dc.contributor.author
서동우
dc.date.accessioned
2018-11-02T04:56:37Z
dc.date.available
2018-11-02T04:56:37Z
dc.date.issued
2015-01
dc.identifier.uri
https://repository.kisti.re.kr/handle/10580/11205
dc.identifier.uri
http://www.ndsl.kr/ndsl/search/detail/report/reportSearchResultDetail.do?cn=TRKO201500002151
dc.description
funder : 미래창조과학부
dc.description
funder : KA
dc.description
agency : 한국과학기술정보연구원
dc.description
agency : Korea Institute of Science and Technology Information
dc.description.abstract
○ 초고성능 컴퓨팅 기반의 생체역학 시뮬레이션을 통해 non-invasive 방식의 순환기계질환 진단 기술 개발
- 순환기계 질환 치료현장 활용에 적합한 3차원 모델 생성 및 적용기술 개발
․ 순환기계 영상데이터 통합 처리 및 고해상도 3차원 혈관 형상데이터 자동 추출/복원 기술
․ 대규모 격자 생성, 최적 해석조건 분석․도출을 위한 대규모/최적 전처리 기술
․ Parameter 기반 3D 가상 혈관 모델 생성 기술 연구
- 슈퍼컴퓨팅 기반 대규모 순환기계 질환 생체역학 시뮬레이션 기술 연구․개발
․ Lattice Boltzmann-Immersed Boundary Method 활용 전산 점도계 Solver 구축
․ 슈퍼컴퓨팅 기반 환자 맞춤형 혈액 특성 적용 Non-Newtonian 시뮬레이션 기술
․ 대규모 혈류 거동 해석 결과의 정밀 분석을 위한 대용량 데이터 처리 및 VR/AR 가시화 기술
- 생체역학 시뮬레이션 결과의 예측 정확도 검증
․ 임상학적 데이터와의 상호 비교를 통한 생체역학 시뮬레이션 결과의 예측 정확도 검증
․ 개발 기술들의 前임상 및 초기 임상시험 등에 향후 적용을 위한 진단 프로세스 최적화 연구
- 국내외 슈퍼컴퓨팅 기반 생체역학 시뮬레이션 기술 분석 및 적용 가능성 연구
․ 미국, 일본 그리고 EU 등에서 추진되는 해당 분야 연구동향 조사
․ 슈퍼컴퓨팅 기반의 차세대 순환기계 질환 진단 및 치료 적용 가능성 연구
dc.description.abstract
The circulatory disease has been currently classified as disease which has been frequently found inthe advanced countries due to aging and known as the main cause of death. According to WHO statistics, average populations who died due to circulatory disease in every year is equivalent to 1/3 in death of the world population that is about 1.67 million. Clinician has also usually taken a diagnostic method that detects the degree of vascular stenosis detected by using pressure drop within the vessel, which is directly measured by inserting pressure wire into the vessel, so called, FractionalFlow Reserve (FFR). However, an invasive interventional method, used to obtain the FFR value, has some practical problems: 1. Pressure wire is expensive for the patients to pay. 2. The method using pressure wire has been physical burden, which has induced artificial stenosis. 3. When doctors need to decide a treatment plan, sometimes he or she misses an appropriate timing for treatments because it is time-consuming and inefficient work-up steps itself.
In our research, we perform flow simulations using supercomputer facilities without other inspections after obtaining three dimensional vessel geometry model using the medical image. Through these modeling and simulation procedures, it can be expected to build the regular strategy for determination of the medical surgery plan. In addition, we summarize the technical elements for development of simulation techniques and prove that the proposed scheme can be applied to real clinical cases.
First of all, patient’s medical imaging data are aligned to the coordinate system suitable for a 3D modeling according to electrocardiography. We then import a patient’s medical image which was converted to the dicom file format, and extract a vascular area through boundary detection from each medical image. After that, we perform a noise rejection, region growing, and partial editing. Upon completion of medical image processing, we generate the cardiovascular 3D mesh model through marching cube algorithm. The 3D models after modified are stored as STL, IGES (CAD file format) and they can be used in the multiple applications.
dc.publisher
한국과학기술정보연구원
dc.publisher
Korea Institute of Science and Technology Information
dc.title
인체 순환기계 질환 극복을 위한 슈퍼컴퓨팅 활용 기초기술 연구
dc.title.alternative
Research for diagnosis system of circulatory diseases using the supercomputer
dc.contributor.alternativeName
Lee, Sang-Min
dc.contributor.alternativeName
Son, Il-Yeop
dc.contributor.alternativeName
Park, Hyeong-Uk
dc.contributor.alternativeName
Seo, Dong-U
dc.identifier.localId
TRKO201500002151
dc.identifier.url
http://www.ndsl.kr/ndsl/commons/util/ndslOriginalView.do?dbt=TRKO&cn=TRKO201500002151
dc.subject.keyword
고성능컴퓨팅
dc.subject.keyword
생체역학 시뮬레이션
dc.subject.keyword
순환기계 질환 진단 시스템
dc.subject.keyword
의료영상 3차원 모델링
dc.subject.keyword
파라메트릭 가상혈관 생성
dc.subject.keyword
High-Performance Computing
dc.subject.keyword
Humodynamics Simulation
dc.subject.keyword
Diagnosis Support System of Circulatory Disease
dc.subject.keyword
3D Modeling using Medical Image
dc.subject.keyword
Virtual Parametric Vessel Model
dc.type.local
최종보고서
dc.identifier.koi
KISTI2.1015/RPT.TRKO201500002151
Appears in Collections:
7. KISTI 연구성과 > 연구보고서 > 2015
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